Gabapentin and Pregabalin Can Interact Synergistically with Naproxen to Produce Antihyperalgesia Anesthesiology American Society of Anesthesiologists

The time course of the antihyperalgesic effect was similar for each fixed-dose ratio and was maximal within 120 min after oral administration (data not shown). No combination of gabapentin and naproxen had an antinociceptive effect on the contralateral, uninjured hind paw (data not shown). Both pregabalin and gabapentin are prescription medications approved to treat seizures and neuropathic pain (postherpetic neuralgia after a shingles outbreak). These antiepileptic medications are structurally similar to the brain chemical GABA (gamma- aminobutyric acid). Both Lyrica and gabapentin work by binding to voltage-gated calcium channels in nerve cells in the central nervous system. Gabapentin is called a central nervous system (CNS)depressant because it slows down some of the functions and processes of the brain.

can you take lyrica and gabapentin together

34–36However, subsequent studies of dorsal root ganglion neurons indicated that gabapentin reduced whole cell Ca2+currents most effectively when test pulses were preceded by depolarization 37,38or activation of protein kinase A. 38Further, gabapentin decreased Ca2+currents in a larger proportion of dorsal root ganglion neurons obtained from rats with chronic constriction or sham surgery of the sciatic nerve compared with unoperated rats. 39Enhanced excitability and sustained membrane depolarization are hallmarks of injury-induced central sensitization of spinal cord neurons. 5,9,23Gabapentin may also produce antihyperalgesia by its ability to decrease glutamatergic transmission in the spinal cord presumably by inhibition of presynaptic VDCC. As just described, the sites at which gabapentin and pregabalin act to produce antihyperalgesia (predominantly the spinal cord) and the sites at which naproxen acts (spinal cord and periphery) appear to be complementary.


To view an interaction report containing 4 (or more) medications, please sign in or create an account. The brand name of pregabalin IR is Lyrica; an extended-release version is Lyrica CR. The FDA approved pregabalin, sold under the brand name Lyrica, in 2004. The FDA initially approved gabapentin in 1993 as the brand Neurontin. These medications work by mimicking the effects of gamma-aminobutyric acid (GABA).

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Gabapentin and Lyrica, together in low doses, will help them to recover from the diseases without affecting their organs. A healthcare provider may need to adjust the dosage when switching to either drug. If you are switching from gabapentin to Lyrica, you will be prescribed a lower dosage of Lyrica. Consult with a healthcare provider to determine whether switching medications is right for you. Lyrica and gabapentin are antiepileptic medications that have a similar mechanism of action. However, Lyrica is absorbed more completely and more quickly into the body than gabapentin.

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If you are not experiencing sufficient pain relief, your provider may increase the dosage of gabapentin. Another meta-analysis compared the effectiveness of gabapentin and pregabalin to duloxetine, an SNRI drug, for nerve pain from DPN. Results found that all three drugs were more effective than a placebo, although they caused some side effects like dizziness or drowsiness. Few head-to-head trials compare the effectiveness of Lyrica and gabapentin for their approved uses. One systematic review and meta-analysis found no significant difference between pregabalin and gabapentin for treating nerve pain.

How Lyrica and gabapentin work] have a synergistic effect in the treatment of pain. Advantages of these compositions [Lyrica with gabapentin] include fewer side effects as lower dosages are needed. This increases patient compliance with the beneficial result of better control of pain. Regarding safety, pregabalin is a controlled substance; gabapentin is not. Both drugs are used to treat certain types ofnerve-related pain in adults.

Lyrica interactions with other medications

However, you should not do this without the supervision and guidance of a healthcare provider. A cohort study investigates the outcomes of substituting gabapentin with pregabalin for patients with peripheral nephropathy. The study found that participants had additional relief in pain scores of approximately 25% at 6 or 12 months after switching to pregabalin from gabapentin. This result includes both participants who responded to gabapentin initially and those who didn’t. Any medicine you consume will give you an accurate result if you take it in the best manner.

Although structurally similar to — and named after — the neurotransmitter gamma-aminobutyric acid (GABA), they do not impact GABA in the brain or work on GABA receptors. It’s reasonable to believe that taking these medications together could further increase the risk. However, this interaction has not been reported with Lyrica and an NSAID. There are possible potential interactions between Lyrica and pain relievers called nonsteroidal anti-inflammatory drugs (NSAIDs).

Clinicians should note that pregabalin has various pharmacokinetic and pharmacodynamic advantages over gabapentin, and a conversion between the 2 medications is often well tolerated. The first scenario involved discontinuing gabapentin and immediately starting pregabalin at the next scheduled can i order lyrica without a prescription dosing period. The other option included a gradual transition from gabapentin to pregabalin. The incidence of peripheral neuropathy is estimated at about 2.4% of the population.1 Of the 14 million US individuals with diabetes, roughly 25% experience painful diabetic neuropathy.

  • The most common side effects of Lyrica include drowsiness, dizziness, dry mouth, edema, gas (flatulence), and weight gain.
  • These were designed to not only look chemically like the central inhibitory neurotransmitter gamma-aminobutyric acid (GABA) but also act like it.
  • Unlike gabapentin, pregabalin increased the PWL of contralateral hind paw.
  • Lyrica is a brand-name drug that can be expensive with or without insurance.
  • This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.

We offer a range of services, including urgent care, primary care, multi-speciality care, mental health, women’s health, nutrition services, and more. Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit.